The course will merge molecular biology and medical genetics to give an up-to-date vision of molecular genetics mechanisms involved in human diseases, with a particular focus on genetic disorders. Besides the theoretical part, large space will be given to practical sessions in which the students will learn how to use genomics data present on the web and how to analyze real DNA and RNA sequencing data.
The “Molecular biology” module will be focused on understanding structure, function, and turnover of macromolecules, structure and regulation of genes and genomes, the mutability of the genome and the mechanisms of DNA repair. The impact of recombinant DNA technologies on basic and applied biomedical research will also be illustrated.
The “Medical genetics” module will illustrate the types and extent of genetic variation seen in the human genome, and how this variation affects disease susceptibility. The module will particularly emphasize how molecular and population genetics have impacted on our understanding of the mechanisms of human disease, providing us with novel diagnostic and therapeutic strategies.
- Teacher: Rosanna Asselta
- Teacher: Giulia Maria Emilia Antonietta Soldà
- Teacher: Letizia Straniero